{"id":1651,"date":"2024-09-11T11:08:49","date_gmt":"2024-09-11T09:08:49","guid":{"rendered":"https:\/\/parviruslab1.unimi.it\/?p=1651"},"modified":"2024-09-12T09:56:28","modified_gmt":"2024-09-12T07:56:28","slug":"progetto-fondazione-cariplo-giovani-ricercatori-2022-2","status":"publish","type":"post","link":"https:\/\/parvirlab.unimi.it\/en\/2024\/09\/11\/progetto-fondazione-cariplo-giovani-ricercatori-2022-2\/","title":{"rendered":"Project Cariplo Foundation \u201cYoung Researchers\u201d 2022"},"content":{"rendered":"\n<div class=\"wp-block-group minicard\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<figure class=\"wp-block-image size-medium is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"426\" src=\"https:\/\/parviruslab1.unimi.it\/wp-content\/uploads\/sites\/118\/2024\/09\/PET-brains-600x426.jpg\" alt=\"\" class=\"wp-image-1652\" style=\"width:435px;height:auto\" srcset=\"https:\/\/parvirlab.unimi.it\/wp-content\/uploads\/sites\/118\/2024\/09\/PET-brains-600x426.jpg 600w, https:\/\/parvirlab.unimi.it\/wp-content\/uploads\/sites\/118\/2024\/09\/PET-brains.jpg 623w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong><em>Molecular mechanisms of NLRP3 inflammasome inhibition by Leishmania infantum-derived factors in the neuropathogenesis of Alzheimer\u2019s disease<\/em><\/strong><\/h2>\n\n\n\n<p><strong>Date: <\/strong>01\/06\/2023 \u2013 31\/05\/2026<\/p>\n\n\n\n<p><strong>Principal investigator:<\/strong> Estefan\u00eda Calvo Alvarez, PhD<\/p>\n<\/div><\/div>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:0px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-medium-font-size\">Summary<\/h3>\n\n\n\n<p>Alzheimer&#8217;s disease (AD) is the most dementing illness, characterized by a gradual loss of cognitive functions. This project will explore the possibility that&nbsp;<em>Leishmania infantum<\/em>&nbsp;parasites, the causative agent of visceral leishmaniasis, may subvert the activation of the microglial NLRP3 inflammasome in the brain of an animal model of Alzheimer&#8217;s disease, leading to neuroprotective and anti-inflammatory effects.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molecular mechanisms of NLRP3 inflammasome inhibition by Leishmania infantum-derived factors in the neuropathogenesis of Alzheimer\u2019s disease Date: 01\/06\/2023 \u2013 31\/05\/2026 Principal investigator: Estefan\u00eda Calvo Alvarez, PhD Summary Alzheimer&#8217;s disease (AD) is the most dementing illness, characterized by a gradual loss of cognitive functions. This project will explore the possibility that&nbsp;Leishmania infantum&nbsp;parasites, the causative agent of [&hellip;]<\/p>\n","protected":false},"author":319,"featured_media":1653,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[41],"tags":[],"class_list":["post-1651","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-funded-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/posts\/1651"}],"collection":[{"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/users\/319"}],"replies":[{"embeddable":true,"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/comments?post=1651"}],"version-history":[{"count":4,"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/posts\/1651\/revisions"}],"predecessor-version":[{"id":1726,"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/posts\/1651\/revisions\/1726"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/media\/1653"}],"wp:attachment":[{"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/media?parent=1651"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/categories?post=1651"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/parvirlab.unimi.it\/en\/wp-json\/wp\/v2\/tags?post=1651"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}